High-precision grassland vegetation coverage remote sensing estimation model is important for quantitative assessment of grassland quality and fine management of grassland.Based on Sentinel-2 multi-spectral remote sensing data and measured sample plots in Inner Mongolia autonomous Region,grassland vegetation coverage was modeled and inverted.The results showed that:1)There was a significant correlation between the 23 vegetation indexes and the measured vegetation coverage (P<0.001),and the highest correlation coefficient was NDVI with a correlation coefficient of 0.834;2)The underestimation of sinusoidal function was more obvious in the high value part (coverage>75%),while the overestimation of linear function was more obvious in the low value part (coverage<25%),by using these two kinds of functions to simulate vegetation coverage,the results were better;3)The grassland types were divided into 6 groups to modeling vegetation coverage respectively.Finally,correlation coefficient between simulated and measured vegetation coverage for the 1 894 sample plots was R²=0.722,P<0.01,RMSE=12%;4)The vegetation coverage of different grassland types in Inner Mongolia from high to low was 78.91% for mountain meadow,73.7% for temperate meadow steppe,53.89% for lowland meadow,52.57% for temperate steppe,32.76% for temperate desert steppe,25.52% for temperate grassland desert and 19.29% for temperate desert.